Identification of Aim2 as a Sensor for DNA Vaccines

Identification of Aim2 as a sensor for DNA vaccines.

Recent human study data have re-established the value of DNA vaccines, especially in priming high-level Ag-specific Ab responses, but also raised questions about the mechanisms responsible for such effects. Whereas previous reports have shown involvement of downstream signaling molecules in the innate immune system, the current study investigated the role of absent in melanoma 2 (Aim2) as a sen...

Identification of Aim2 as a Sensor for DNA

Identification of AIM2 as a downstream target of JAK2V617F

BACKGROUND The gain-of-function mutation JAK2V617F is frequently found in Philadelphia-chromosome-negative myeloproliferative neoplasm (MPN) patients. However, the tumorigenic properties of JAK2V617F have mostly been characterized in in vivo and in vitro murine models due to the lack of appropriate human cell lines. METHODS Using the multipotent hematologic cell line UT-7/GM, we established D...

assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.

چکیده ندارد.

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune sensor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Production of inflammasome-associated cytokines and other inflammatory mediators...